2 weeks ago

DMPK Scientist (m/f/d)

AC €100k+Bonus Permanent

Have a look at the fulfilling work on offer:

  • You serve as DMPK project representative on global discovery and development programs
  • You provide metabolism and drug-drug interaction guidance to discovery project teams to mitigate issues such as “soft spot identification,” “major metabolites” to enable identification of high quality “first in man” candidates
  • You lead the interpretation of metabolite ID studies conducted at CROs and serve as internal expert on structure elucidation, metabolic pathways and reactive metabolite formation
  • You serve as bio-transformation subject matter expert providing expert guidance on metabolic pathways of small molecules and alternate modalities such as anti-sense oligonucleotides, peptides, etc.
  • You demonstrate high proficiency across a wide range of in vitro/ in vivo DMPK technologies and are capable of initiating new areas of investigation that are scientifically meaningful in supporting drug discovery projects
  • You monitor project progress with CROs and provide timely and valuable guidance to enable studies being executed appropriately
  • You support human dose projection calculations and support clinical pharmacology trial design based on DDI risk analysis based on nonclinical data and refining based on clinical data

Let your talent flourish

  • You hold a PhD in Drug Metabolism/ Pharmacokinetics or related discipline
  • You have demonstrated extensive experience in conducting/ managing DMPK studies (in vitro and in vivo) at CROs
  • You have demonstrated knowledge in interpreting met-id data and proposing metabolic pathways across species
  • You have experience or knowledge in bioanalytical methods and technologies for small molecules and biologics and in biomarker assays
  • You have experience in working and delivering projects within highly outsourced and matrixed environments across diverse geographies and working cultures
  • You have a proven track record in leading and working in teams based upon a matrix reporting
  • You have a broad understanding of various DMPK relevant areas such as physicochemical properties, drug-metabolizing enzyme & transporter kinetics, pharmacokinetics, mechanistic biotransformation, analytical sciences and PK/dose modelling
  • You have strong interpersonal, communication, presentation, and negotiation skills
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