2 weeks ago

Head Toxicology

AC TBC Permanent

Start Date: ASAP

Have a look at the fulfilling work on offer

  • You lead the Toxicology team and are responsible for all target-based safety assessments, preclinical safety assessments and implement discovery toxicology strategies to enable the progression of optimized drug candidates
  • You develop overall toxicology plans for lead candidates for Ph I to Ph III
  • You provide strategic guidance for project teams and senior management including evaluation of conclusions and potential impact of toxicology results on program and clinical/ regulatory strategy
  • You lead the development of early hypothesis-driven investigation into mechanisms of toxicity for the proactive management of potential safety liabilities and communication of impact to teams
  • You are responsible for the safety strategy and input to multi-disciplinary drug-hunting project teams
  • You represent Preclinical Development on Discovery and Development teams and interface with internal and external colleagues to ensure timely and accurate dissemination of nonclinical safety strategies as well as results to drive the portfolio strategically
  • You monitor toxicology studies; review, summarize, interpret and integrate complex data sets across multiple disciplines; finalize as submission-ready documents for regulatory authorities
  • You address and resolve scientific issues arising in drug discovery/ development programs

Let your talent flourish

  • You hold a PhD in Toxicology or closely related field with several years' experience in a drug discovery/ development setting of a biopharmaceutical company
  • You have a proven track record of making major contributions to the discovery of one or more marketed or in-development medicines, incl. designing, monitoring, and interpreting toxicology studies to support clinical development of candidate therapeutic agents
  • You have expert knowledge of nonclinical data packages needed to support first in human studies, clinical development and product registration
  • You have extensive experience of regulatory toxicology/ pathology
  • You have strategic leadership/ managerial competencies
  • You are familiar with more than one of the following therapeutic modalities preferred: small or large molecules, cell and gene therapy
  • You are a can-do person, problem solver who takes hands on approach to driving projects forward
  • You have expert knowledge of GLP regulations and experience in the oversight of contracted studies
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